The rabbit hypercholesterolemia model that induces atherosclerosis by feeding rabbits a high-cholesterol diet is perhaps the most well-know of the models, resulting in notable vascular lesions after only a few weeks. This model is very useful as it has been found to be highly reproducible with minimal variation between animals and transferable between laboratories. A further model, referred to as normolipemic, causes atherosclerotic lesions through indwelling aortic polyethylene catheter, balloon angioplasty or nitrogen exposure. Some laboratories used a combination of these two methods.
Key advantages to using rabbits as experimental models for ophthalmic research are the size of the rabbit eye, a large body of accumulated data on the anatomy and physiology of the rabbit eye, and most importantly its similarity to the human eye Gwon The rabbit model is most often used to study surgical interventions such as cataract removal, intraocular lens insertion, corneal transplantation, laser refractive procedures, glaucoma shunt implantation, and intra-vitreal drug delivery.
Uveal melanoma UM is the most frequent primary intraocular tumor in adults Singh and Topham and differs from cutaneous melanoma in several aspects. To date several UM cell lines have been used in rabbits to study the cancer. A novel model of retinoblastoma, induced by injection of cultured human retinoblastoma cells into the sub-retinal space of immunosuppressed rabbits, results in intraocular tumors after one week.
These tumors are significantly similar to those occurring in humans.
This is an advantage as vitreous seeds only develop very late in mouse models; failure to eliminate these is considered to be the cause of treatment failures in humans. Further areas of research using the rabbit eye as a model include retinal detachment and proliferative vitreoretinopathy PVR , retinoblastoma, and retinitis pigmentosa RP.
PVR is characterized by an abnormal wound healing process that occurs after retinal detachment or other ocular trauma, exhibiting excessive inflammation within the eye. Research focused on elucidating intra-ocular inflammation is needed. The rabbit PVR model is key to underpinning that effort. There are a several human infectious diseases for which rabbits have been considered as a model, among them:. The model for tuberculosis is perhaps the best fitting model with the least compromises.
Tuberculosis TB is still a major cause of morbidity and mortality; this applies specifically in some developing countries. The lack of an effective vaccine, increasing drug resistance, and high cost of long-term treatments mean that tuberculosis has not been effectively controlled. It is estimated that nine million new cases occurred annually, worldwide; leading to one and a half million deaths. In healthy individuals T cells and macrophages are the main line of defense against M. Immunocompromised patients lack or have poorly formed granulomas. However, bacteria may become dormant inside granulomas leading to latent infections.
To investigate, three animal models have been considered for TB research: rabbits, guinea pigs, and mice. While mice have advantages in the lab, they are relatively resistant to tuberculosis infection. Next in susceptibility are rabbits, with guinea pigs showing even more susceptibility to infection than mice and rabbits.
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Clinical-grade stem cell—derived retinal pigment epithelium patch rescues retinal degeneration in rodents and pigs. Science Translational Medicine , Jan.
ScienceDaily, 16 January Researchers rescue photoreceptors, prevent blindness in animal models of age-related macular degeneration: Findings set stage for first clinical trial of stem cell-based therapeutic approach for AMD. Retrieved September 23, from www. These findings provide a more Below are relevant articles that may interest you. ScienceDaily shares links with scholarly publications in the TrendMD network and earns revenue from third-party advertisers, where indicated. On the Keto Diet? Ditch the Cheat Day Boy or Girl? Living Well.
View all the latest top news in the environmental sciences, or browse the topics below:. Electrosprayed nanoparticles and electrospun nanofibers based on natural materials: applications in tissue regeneration, drug delivery and pharmaceuticals. Chem Soc Rev. A bispecific crossmab antibody optimized for neovascular indications of the eye: combining dual inhibition of Vascular endothelial growth factor-A and angiopoietin-2 with an effectorless Fc domain. IF: 8.
Cell Rep. Sci Rep. AAV-mediated gene delivery of the calreticulin anti-angiogenic domain inhibits ocular neovascularization. Evaluation of subconjunctival liposomal steroids for the treatment of experimental uveitis. A novel model of persistent retinal neovascularization for the development of sustained anti-VEGF therapies. Exp Eye Res, Sep — Contact us Dr Velachamy A Barathi at amutha.
A new dry eye mouse model produced by exorbital and intraorbital lacrimal gland excision
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